A special issue on Nucleoside/Nucleotide or Nucleic Acid Modification has been compiled as a part of the Guest Editorship invitation from Wiley for the journals, The Chemical Record and Asian Journal of Organic Chemistry. Feel free to contact me or other editors for a contribution.
Our developed water-soluble ligand KapdiPhos ( 4-((1R,3R,5S,7R)-1,3,5-Triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate or PTABS) in combination with Pd precursor has proved to be highly efficient in catalyzing room temperature amination, low temperature etherification and thioetherification of chloroheteroarenes. Low temperature and pressure carboamidation of DMT protected nucleosides also can be achieved.
KapdiPhos (PATBS) is now available commercially from Strem Chemicals Inc. https://www.strem.com/catalog/v/15-5715/phosphorus_1430837-91-4
C-C Bond forming technologies for heteroarene modification via transition-metal catalyzed processes such as cross-coupling & C-H bond functionalizations have dominated the literature for the past several decades. Our group has been working towards the development of newer technologies that could provide a more efficient, ambient temperature protocols for the functionalization of commercially and biologically relevant heteroaryl substrates. Our results with Palladium as well as Copper in combination with PTABS (KapdiPhos) suggests a new coordination/activation metal-mediated SNAr of chloroheteroarenes.
Prof. Lakshman will be with us for 3 months in 2022 and 2-3 months in 2023. Collaboratively, we will be developing efficient routes towards important nucleoside-based antivirals.