Bicyclic caged phosphines are unique ligand systems with properties that are unmatched compared to the normal phosphines. Limited degree of freedom coupled with steric and electronic factors that can be easily regulated, provide extra potential for the caged ligands to find applications in catalytic reactions wherein other ligands have either failed or shown lower reactivity. In literature, many such examples of caged ligands in combination with metal precursors providing enhanced reactivity than their other phosphines counterparts have been reported. Verkade with the Proazaphosphatrane ligand sytems revolutionized this field with many excellent contributions, however the application of caged ligands reduced drastically post-Verkade era until recently. The past decade has seen a major resurgence in the synthesis and application of caged ligands with research groups including ours have been able to provide convincing proof about the versatility of these ligands in the form of many state-of-the-art catalytic protocols that have found applications in academia as well as industrial processes. PTABS (Kapdiphos) developed in our research lab at ICT is now commercially available in all the leading chemical companies such as
Toronto Research Chemicals (https://lnkd.in/dTDZEMps)
For more information check out our papers in this area
The development of novel water-soluble Pd/Cu based catalytic systems is for the efficient modification of natural nucleosides as they lack fluorescent properties while the incorporation of fluorophores on to the nucleoside backbone would allow the formation of functional molecules.
Our group has been actively involved in studying and providing evidence for several proposed mechanisms in literature as well as identifying new catalytic mechanisms.